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The PBPK model for a chemical comprises a mechanistically-based description of its uptake, distribution and clearance (Haddad et al, 1998) These models are generally used to perform analysis on an individual basis although they can take account of variability in populations They can include tissue metabolism and protein binding and are, therefore, useful in toxicological risk assessment They allow examination of the impact of biochemical processes on the pharmacokinetics of a particular chemical In addition, they can be used to describe the impact of pharmacokinetic factors on the variability of individual risk For example, they can be used to determine the impact of differences in key metabolism enzymes within a general population (Clewell & Andersen, 1996) These include differences resulting from multiple genotypic expression including cytochrome P450 polymorphisms as well as normal variation in enzyme activities.

71 72

These specialized courts, or problem-solving courts as they increasingly are becoming known, include drug treatment courts (Hora, Schma and Rosenthal, 1999; Winick and Wexler, in press); domestic violence courts (Fritzler and Simon, 2000; Winick, 2000a); mental health courts (Fritzler, in press; Lurigio et al, 2001); teen courts (Schiff and Wexler, 1996; Wexler, 2000); and others Compared to conventional courts, these problemsolving courts play a more direct and proactive role in the treatment and rehabilitative process Wexler (2001) discusses the role of the judge in criminal court settings, borrowing on mental health compliance principles, cognitive self change programs to address relapse prevention, and a desistance model springing from recent research that sees rehabilitation as a maintenance process that can be aided by a judge s public endorsement of an offender s changed behavior.

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The type pre x used here follows 3GPP terminology. 3GPP Release 6 includes performance requirements for a number of di erent enhanced UEs. The gain from using linear minimum mean-squared error (LMMSE) receivers predominantly comes from equalizing time-dispersive radio towards the serving HS-DSCH cell. Equalizing the radio channel results in a better equivalent downlink orthogonality factor and, therefore, less own-cell interference. The gain from using LMMSE is, therefore, primarily available to users that are dominated by own-cell interference while experiencing relatively high

Whilst primarily developed to evaluate human risk in relation to drug development, PBPK models are now also being applied to environmental risk assessment This, however, can and should be developed much further and potentially applied, for example, to sh-.

Moreover, in addition to these specialized courts, trial judges serving in more general courts and appellate judges have increasingly become sensitive to the fact that the way they play their roles have therapeutic consequences for those affected (Seattle University Law Review, Symposium Issue, 2000; Rottman, 2000) (See 10 by Simon in this volume) Research is just beginning to surface emphasizing that, within these courts, the therapeutic effects of judges, defendants, and victims are important and should be studied The components of the court process itself, from administrative/organizational concerns to what was actually said and how this might impact the therapeutic nature of the exchange for the judge and the defendant was studied in a domestic violence court ethnographic study (Petrucci, 2002) Therapeutic effects of the judicial process on the judges themselves was the focus of another recent study.

Proof If W is an item set such that |W| = k + 1, then we already know that W is the union of two subsets U, V of I such that |U| = |V | = k and that Z = U V has k 1 elements Since W is a -frequent item set and Z, U, V are subsets of W, it follows that each of these sets is also a -frequent item set Note that the reciprocal statement of Theorem 3 is not true, as the next example shows Example 6 Let T be the transaction data set introduced in Example 3 Note that both i1 i2 and i1 i3 are 1 -frequent item sets; however, 3 suppT (i1 i2 i3 ) = 0, so i1 i2 i3 fails to be a 1 -frequent item set 3 The procedure apriori gen mentioned above is introduced next.

Table Answer 3.5-7

Chase and Hora (2000) compared judicial attitudes across two groups of judges: drug treatment court judges using therapeutic jurisprudence and family court judges who did not They asked several questions of the 194 judges who participated in their survey Did drug treatment.

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